Nutritional Composition of Residues Available for Ruminants from Rice + Cowpea Intercrop During the Dry Season in Nigeria

Chemical analysis to assess the mineral status of two fodder crops (rice and cowpea) was carried out. The range of P, K, Na, Ca and Mg values in the rice and cowpea plants met the minimum requirements for beef and dairy cattle and sheep/goats in this area. In rice plants, the level of crude protein (CP) met the marginal requirement, while CP values of cowpea were within the recommended requirements for ruminants in the area of study. Values of Fe and Zn were below minimum requirements while over 50% of the rice and cowpea plants had adequate Cu. Mineral supplements are suggested for correction of deficiencies in feed of ruminants in the area of study. Keywords: crop residues, mineral supplements, macro elements, microelements, ruminant

Nutritional Composition of Residues Available for Ruminants from Rice + Cowpea Intercrop During the Dry Season in Nigeria

Chemical analysis to assess the mineral status of two fodder crops (rice and cowpea) was carried out. The range of P, K, Na, Ca and Mg values in the rice and cowpea plants met the minimum requirements for beef and dairy cattle and sheep/goats in this area. In rice plants, the level of crude protein (CP) met the marginal requirement, while CP values of cowpea were within the recommended requirements for ruminants in the area of study. Values of Fe and Zn were below minimum requirements while over 50% of the rice and cowpea plants had adequate Cu. Mineral supplements are suggested for correction of deficiencies in feed of ruminants in the area of study. Keywords: crop residues, mineral supplements, macro elements, microelements, ruminant

Changes in anti-viral effectiveness of interferon after dose reduction in chronic hepatitis C patients: a case control study

BACKGROUND: High dose interferon induction treatment of hepatitis C viral infection blocks viral production over 95%. Since dose reduction is often performed due to clinical considerations, the effect of dose reduction on hepatitis C virus kinetics was studied. METHODS: A new model that allowed longitudinal changes in the parameters of viral dynamics was used in a group of genotype-1 patients (N = 15) with dose reduction from 10 to 3 million units of interferon daily in combination with ribavirin, in comparison to a control group (N = 9) with no dose reduction. RESULTS: Dose reduction gave rise to a complex viral kinetic pattern, which could be only explained by a decrease in interferon effectiveness in blocking virion production. The benefit of the rapid initial viral decline following the high induction dose is lost after dose reduction. In addition, in some patients also the second phase viral decline slope, which is highly predictive of success of treatment, was impaired by the dose reduction resulting in smaller percentage of viral clearance in the dose reduction group. CONCLUSIONS: These findings, while explaining the failure of many induction schedules, suggest that for genotype-1 patients induction therapy should be continued till HCVRNA negativity in serum in order to increase the sustained response rate for chronic hepatitis C

An adverbial approach for the formal specification of topological constraints involving regions with broad boundaries

Topological integrity constraints control the topological properties of spatial objects and the validity of their topological relationships in spatial databases. These constraints can be specified by using formal languages such as the spatial extension of the Object Constraint Language (OCL). Spatial OCL allows the expression of topological constraints involving crisp spatial objects. However, topological constraints involving spatial objects with vague shapes (e.g., regions with broad boundaries) are not supported by this language. Shape vagueness requires using appropriate topological operators (e.g., strongly Disjoint, fairly Meet) to specify valid relations between these objects; otherwise, the constraints cannot be respected. This paper addresses the problem of the lack of terminology to express topological constraints involving regions with broad boundaries. We propose an extension of Spatial OCL based on a geometric model for objects with vague shapes and an adverbial approach for topological relations between regions with broad boundaries. This extension of Spatial OCL is then tested on an agricultural database

Quantized spin waves in the metallic state of magnetoresistive manganites

High resolution spin waves measurements have been carried out in ferromagnetic (F) La(1-x)(Sr,Ca)xMnO3 with x(Sr)=0.15, 0.175, 0.2, 0.3 and x(Ca)=0.3. In all q-directions, close to the zone boundary, the spin wave spectra consist of several energy levels, with the same values in the metallic and the x\approx 1/8 ranges. Mainly the intensity varies, jumping from the lower energy levels determined in the x\approx 1/8 range to the higher energy ones observed in the metallic state. On the basis of a quantitative agreement found for x(Sr)=0.15 in a model of ordered 2D clusters, the spin wave anomalies of the metallic state can be interpreted in terms of quantized spin waves within the same 2D clusters, embedded in a 3D matrix.Comment: 4 pages, 5 figure

Management of visual clutter in annotated 3D CAD models: A comparative study

The use of annotations in CAD models has been an active area of research because of their ability to connect design information to specific aspects of the model s geometry. The effectiveness of annotations is determined by the ability to clearly communicate information. However, annotations can quickly create clutter and confusion as they increase both in number and complexity. Consequently, efficient interaction and visualization mechanisms become crucial. Despite recent standardizations of procedures for the presentation of textual information in CAD models, no explicit guidelines are available as to how to make annotated models more readable and manageable. In this paper, we present the results of a comparative study of different mechanisms to manage visual clutter in annotated 3D CAD models and offer recommendations based on our findings. Our results show that even basic interaction mechanisms have a substantial impact on user s performanceCamba, J.; Contero, M.; Johnson, M. 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Positions, Regions, and Clusters: Strata of Granularity in Location Modelling

Abstract. Location models are data structures or knowledge bases used in Ubiquitous Computing for representing and reasoning about spatial relationships between so-called smart objects, i.e. everyday objects, such as cups or buildings, containing computational devices with sensors and wireless communication. The location of an object is in a location model either represented by a region, by a coordinate position, or by a cluster of regions or positions. Qualitative reasoning in location models could advance intelligence of devices, but is impeded by incompatibilities between the representation formats: topological reasoning applies to regions; directional reasoning, to positions; and reasoning about set-membership, to clusters. We present a mathematical structure based on scale spaces giving an integrated semantics to all three types of relations and representations. The structure reflects concepts of granularity and uncertainty relevant for location modelling, and gives semantics to applications of RCC-reasoning and projection-based directional reasoning in location models

The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2•72 (95% uncertainty interval [UI] 2•66–2•79) in 2000 to 2•31 (2•17–2•46) in 2019. Global annual livebirths increased from 134•5 million (131•5–137•8) in 2000 to a peak of 139•6 million (133•0–146•9) in 2016. Global livebirths then declined to 135•3 million (127•2–144•1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2•1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27•1% (95% UI 26•4–27•8) of global livebirths. Global life expectancy at birth increased from 67•2 years (95% UI 66•8–67•6) in 2000 to 73•5 years (72•8–74•3) in 2019. The total number of deaths increased from 50•7 million (49•5–51•9) in 2000 to 56•5 million (53•7–59•2) in 2019. Under-5 deaths declined from 9•6 million (9•1–10•3) in 2000 to 5•0 million (4•3–6•0) in 2019. Global population increased by 25•7%, from 6•2 billion (6•0–6•3) in 2000 to 7•7 billion (7•5–8•0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58•6 years (56•1–60•8) in 2000 to 63•5 years (60•8–66•1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation: Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens